ADDICTION, ABUSE AND MISUSE: Tramadol hydrochloride tablets expose patients and other users to the risks of opioid addiction, abuse and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing tramadol hydrochloride tablets, and monitor all patients regularly for the development.
(ng/mL) Time to Peak (hrs) Clearance/F † (mL/min/Kg) t 1/2 (hrs) Healthy Adults. Population/ Dosage Regimen * Parent Drug/ Metabolite Peak Conc. Figure 1: Mean Tramadol and M1 Plasma Concentration Profiles after a Single 100 mg Oral Dose and after Twenty-Nine 100 mg Oral Doses of Tramadol Hydrochloride given four times per day.
Tramadol hydrochloride tablets are contraindicated in patients with:
ACCIDENTAL INGESTION : Accidental ingestion of tramadol hydrochloride tablets, especially by children, can be fatal (see WARNINGS ).
NEONATAL OPIOID WITHDRAWAL SYNDROME : Prolonged use of tramadol hydrochloride tablets during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts.
Tramadol HCL is a prescription pain reliever that is used to treat moderate, severe or chronic pain. This medication will need to be taken properly to minimize your risk of side effects or addiction to Tramadol HCL.
Possible Side Effects Common side effects of Tramadol include sweating, drowsiness, sleepiness, stomachache, tiredness, dry mouth, headache, being sick or constipation. Keep Tramadol capsules in areas below 30 degrees C and out of the reach of children.
Tramadol HCl Ext-Rel Tabs (Tramadol) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Moderate to moderay severe chronic pain when around-the-clock treatment for an extended time is needed.
Various generic manufacturers. Tramadol HCl 100mg, 200mg, 300mg.
Usual range: 200–300mg/day. Swallow whole. Max 300mg/day. <16yrs: not recommended. Not currently on tramadol: 100mg once daily; may increase every 2–3 days by 100mg/day. Currently on immediate-release tramadol: Switch to ext-rel at same daily dose or rounded down to nearest 100mg increment. Take once daily (allow 24hrs in between doses). Withdraw gradually.
Tramadol HCl. CAS No. . C16H25NO2. HCl M.W. 263.38 36.46. T-061. Tramadol HCl, N-Desmethyl Tramadol HCl. CAS No. . C15H23NO2. HCl M.W. 249.36 36.46. T-062. N-Desmethyl Tramadol HCl, Tramadol EP Impurity D HCl. CAS No. . C15H23NO2. HCl M.W. 249.36 36.46.
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