(i) micronizing a pharmaceutically active agent, wherein said pharmaceutically active ingredient is tramadol hydrochloride, which is freely soluble in water, wherein the pharmaceutically active agent is micronized to a particle size having an upper size limit of about or less than 125 micron (120 mesh) and a.
Description of the Related Art. 2.
In certain embodiments, such a pharmaceutical composition, upon oral administration in a dog, further provides a C max of M1 of about or less than 2 μg/mL. In certain embodiments, the pharmaceutically active agent is tramadol, and upon oral administration in a dog, the pharmaceutical composition provides an AUC (0 to infinity) (plasma concentration versus time) of the active metabolite of tramadol, M1 (O-desmethyltramadol), about or greater than 0.2, 0.4, 0.6, 0.8, 1.0, or 1.2 μg hr/mL.
In certain embodiments, the pharmaceutically active agent contributes about or greater than 15%, 20%, 30%, 40%, 50%, or 60% of the total weight of the pharmaceutical composition.
In one aspect, the present invention provides a pharmaceutical composition comprising (i) a pharmaceutically active agent having a high water solubility, a high daily dose, and a short half-life, and (ii) a matrix that comprises a hydrophilic polymer, wherein the pharmaceutically active agent is micronized and dispersed in the matrix.
The pharmaceutical compositions may have one or more of the following characteristics: (1) providing sustained plasma levels of pharmaceutical active agents, including those of a high water solubility, short half life, and/or high dose; (2) capable of high drug loading (e.g., containing drug content in an amount of about or greater than 50% of the total weight of the pharmaceutical composition); (3) suitable for both human and veterinary uses; and (4) capable of being in a once-a-day or twice-a-day dosage form.
Patient information for ZYDOL SOLUBLE TABLETS Including dosage instructions and possible side effects. Tramadol - the active substance in ZYDOL - is a painkiller belonging to the class of opioids that acts on the central nervous. Always dissolve the ZYDOL in about 50 ml of water (about half a cup full) and drink the.
We comply with the HONcode standard for trustworthy health information - verify here.
To view content sources and attributions, please refer to our editorial policy. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Dec 4th, 2017), Cerner Multum (updated Dec 5th, 2017), Wolters Kluwer (updated Dec 1st, 2017) and others.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.
More drug information updates.
Subscribe to receive notifications whenever new articles are published.
If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist. Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. This information has been compiled for use by healthcare practitioners and consumers in the United States. Drug information contained herein may be time sensitive. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient.
Click here for US version. UK Edition. Expand Transcript.
Source: Medicines and Healthcare Products Regulatory Agency.
Abstract: In the present study Elementary osmotic pump (EOP) of highly water soluble drug tramadol hydrochloride. (TRH) was developed and evaluated. Target release profile was selected and different variables were optimized to achieve the same. Formulation variables like levels of swellable polymer (10-21.87 %) and.
Authors: Kumar, Pramod ; Singh, Sanjay ; Mishra, Brahmeshwar.
Publisher: Bentham Science Publishers DOI: https://doi.org/10.2174/
Source: Current Drug Delivery, Volume 6, Number 1, January 2009, pp.
$55.00 plus tax ( Refund Policy ).
Keywords: Elementary osmotic pump ; semipermeable membrane ; swellable polymer ; tramadol hydrochloride.
Document Type: Research Article Publication date:
Pressing the buy now button more than once may result in multiple purchases.
Detox ultram tramadol can tramadol cause headaches etodolac and tramadol soma tramadol fioricet amneal pharmaceuticals tramadol no prior prescription tramadol dolor ibuprofeno tramadol how long is tramadol st buy tramadol online no medical records tramadol water soluble tramadol apap 35.7 325t.
Seasons Greetings From Giant Bomb.
Call of Duty's return to World War II looks great, but feels flat and uninspired from start to finish.
Log in to comment.
Send tramadol7148m a private message Use your keyboard!
Electronic Arts makes missteps at every turn in this fundamentally flawed follow-up.
Become Premium to Watch.
This rollercoaster ride of a turn-based strategy game starts out almost impossibly strong, but by the end I mostly wished it'd been over three hours earlier.
5.0, AA hydrogels swell significantly above pH 5, which is the pH of the small intestine. Therefore, one of the major potential applications of acrylic acid gels is in sustained gastro-intestinal drug-delivery systems [12, 13]. Polyvinylpyrrolidone. (PVP), a synthetic polymer, has excellent water solubility and biocompatibility. Ad.