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Is tramadol water soluble


3.9.2018 | Robert Albertson
Is tramadol water soluble

(i) micronizing a pharmaceutically active agent, wherein said pharmaceutically active ingredient is tramadol hydrochloride, which is freely soluble in water, wherein the pharmaceutically active agent is micronized to a particle size having an upper size limit of about or less than 125 micron (120 mesh) and a.

Description of the Related Art. 2.

In certain embodiments, such a pharmaceutical composition, upon oral administration in a dog, further provides a C max of M1 of about or less than 2 μg/mL. In certain embodiments, the pharmaceutically active agent is tramadol, and upon oral administration in a dog, the pharmaceutical composition provides an AUC (0 to infinity) (plasma concentration versus time) of the active metabolite of tramadol, M1 (O-desmethyltramadol), about or greater than 0.2, 0.4, 0.6, 0.8, 1.0, or 1.2 μg hr/mL.

In certain embodiments, the pharmaceutically active agent contributes about or greater than 15%, 20%, 30%, 40%, 50%, or 60% of the total weight of the pharmaceutical composition.

In one aspect, the present invention provides a pharmaceutical composition comprising (i) a pharmaceutically active agent having a high water solubility, a high daily dose, and a short half-life, and (ii) a matrix that comprises a hydrophilic polymer, wherein the pharmaceutically active agent is micronized and dispersed in the matrix.

The pharmaceutical compositions may have one or more of the following characteristics: (1) providing sustained plasma levels of pharmaceutical active agents, including those of a high water solubility, short half life, and/or high dose; (2) capable of high drug loading (e.g., containing drug content in an amount of about or greater than 50% of the total weight of the pharmaceutical composition); (3) suitable for both human and veterinary uses; and (4) capable of being in a once-a-day or twice-a-day dosage form.


6.12.2018 | Destiny Laird
Is tramadol water soluble

Patient information for ZYDOL SOLUBLE TABLETS Including dosage instructions and possible side effects. Tramadol - the active substance in ZYDOL - is a painkiller belonging to the class of opioids that acts on the central nervous. Always dissolve the ZYDOL in about 50 ml of water (about half a cup full) and drink the.

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Source: Medicines and Healthcare Products Regulatory Agency.

Development and Evaluation of Elementary

12.18.2018 | Destiny Laird
Is tramadol water soluble

Abstract: In the present study Elementary osmotic pump (EOP) of highly water soluble drug tramadol hydrochloride. (TRH) was developed and evaluated. Target release profile was selected and different variables were optimized to achieve the same. Formulation variables like levels of swellable polymer (10-21.87 %) and.

Authors: Kumar, Pramod ; Singh, Sanjay ; Mishra, Brahmeshwar.

Publisher: Bentham Science Publishers DOI:

Source: Current Drug Delivery, Volume 6, Number 1, January 2009, pp.

$55.00 plus tax ( Refund Policy ).

Keywords: Elementary osmotic pump ; semipermeable membrane ; swellable polymer ; tramadol hydrochloride.

Document Type: Research Article Publication date:

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Tramadol reviews

11.17.2018 | Robert Albertson
Is tramadol water soluble

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Swelling and Controlled Release of Tramadol Hydrochloride from a

9.15.2018 | Alexander Mercer
Is tramadol water soluble

5.0, AA hydrogels swell significantly above pH 5, which is the pH of the small intestine. Therefore, one of the major potential applications of acrylic acid gels is in sustained gastro-intestinal drug-delivery systems [12, 13]. Polyvinylpyrrolidone. (PVP), a synthetic polymer, has excellent water solubility and biocompatibility. Ad.

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