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Okeliten.orgAspirin vs tramadol

Tramadol Hydrochloride Analgesic Efficacy Compared with


12.29.2018 | Makayla Blare

Professor, Pharmacology, 614 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15261.

Aspirin vs tramadol
Tramadol Hydrochloride Analgesic Efficacy Compared with

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Relative to codeine, tramadol has similar analgesic properties but may have fewer constipating, euphoric, and respiratory depressant effects. Tramadol 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication, whereas tramadol 50 mg was statistically superior to placebo only for remedication time. Gastrointestinal side effects (nausea, dysphagia, vomiting) were reported more frequently with tramadol 100 mg, ASA/codeine, and codeine 60 mg than with placebo. A two-center randomized double-blind controlled clinical trial was performed to assess the analgesic efficacy and reported side effects of tramadol 100 mg, tramadol 50 mg, codeine 60 mg, aspirin (ASA) 650 mg with codeine 60 mg, and placebo. Of the 200 patients enrolled, seven provided incomplete efficacy data or discontinued prematurely and one was lost to follow-up. Using a third molar extraction pain model, 200 healthy subjects were enrolled in a 6-hour evaluation after a single dose of drug. ASA/codeine was found to be statistically superior to placebo for all measures of efficacy. The 6-hour TOTPAR scores for the tramadol groups and ASA/codeine group were not significantly different. A greater TOTPAR response compared with all other active measures was seen for ASA/codeine during the first 3 hours of study. Tramadol hydrochloride is a novel, centrally acting analgesic with two complementary mechanisms of action: opioid and aminergic. Codeine was not found to be statistically superior to placebo for any efficacy measure. Using standard measures of analgesia, including total pain relief score (TOTPAR), maximum pain relief score (MaxPAR), sum of pain intensity difference scores (SPID), peak pain intensity difference (Peak PID), remedication, and global evaluations, all active treatments were found to be numerically superior to placebo.

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Aspirin vs tramadol