Use lowest effective dose for shortest duration. Swallow whole. Take once daily with liquid; allow 24hrs in between doses. ≥18yrs: Not currently on tramadol: initially 100mg once daily; titrate up as needed by 100mg increments every 5 days. Currently on immediate-release tramadol: switch to ext-rel at total daily dose.
Pain severe enough to require daily, around-the-clock, long term opioid treatment and for which alternative treatment options are inadequate.
≥18yrs: Not currently on tramadol: initially 100mg once daily; titrate up as needed by 100mg increments every 5 days. Conversion from other opioids: see full labeling. Elderly: titrate slowly; monitor. Currently on immediate-release tramadol: switch to ext-rel at total daily dose rounded down to nearest 100mg increment. Swallow whole. Max 300mg/day. Withdraw gradually by 25–50% every 2–4 days. Concomitant use or discontinuation of CYP2D6 inhibitors, CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments (see full labeling). Take once daily with liquid; allow 24hrs in between doses. Use lowest effective dose for shortest duration.
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Use only if alternative treatment options (eg, non-opioid analgesics, immediate-release opioids) are ineffective, not tolerated, or otherwise inadequate to provide sufficient management of pain. Not for use as an as-needed (prn) analgesic.
Company: Vertical Pharmaceuticals. Generic Name and Formulations: Tramadol HCl 100mg, 200mg, 300mg; ext-rel caps.
TRAMADOL · tramadol hydrochloride 100 mg/mL oral liquid, 10 mL · tramadol hydrochloride 100 mg/2 mL injection, 5 x 2 mL ampoules · tramadol hydrochloride 100 mg modified release tablet, 20 · tramadol hydrochloride 50 mg capsule, 20 · tramadol hydrochloride 200 mg modified release tablet, 20 · tramadol.
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