Pregabalin antinociception and its interaction with tramadol in acute model of pain. Meymandi MS(1), Keyhanfar F. Author information: (1)Department of Pharmacology, Tehran University of Medical Sciences, Hemmat Pardis, Hemmat highway, Tehran, Iran. BACKGROUND: The aim of present study was to.
The antinociceptive effect of intraperitoneal administration of pregabalin (1 to 400 mg/kg) and tramadol (10 to 80 mg/kg) or combination of them were measured after 30 and 60 min on hot-plate in terms of maximum possible effect (%MPE) in mice.
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From linear equation the doses that increased antinociceptive effect by 50% (ED(50)) were 69 ± 8.2 mg/kg for tramadol and 246 ± 24 mg/kg for pregabalin. Unlike pregabalin, %MPE(30) (at 30(th) min) of tramadol was significantly higher than its %MPE(60). The interaction after co-administration of non analgesic dose of 10 mg/kg of pregabalin with low analgesic dose of 30 mg/kg of tramadol resulted super-additive and %MPE(30) and %MPE(60) were increased compared to each drug alone. In all other combination groups, the interaction were sub-additive particularly when non analgesic doses of each drug (10 mg/kg) were co-administrated and %MPE was decreased significantly compared to that of each drug alone. Antinociceptive effect rose significantly for both pregabalin at doses 200 and 400 mg/kg and tramadol from 20 to 80 mg/kg in dose dependent manner.
Pregabalin revealed a comparative antinociceptive effect as similar to tramadol in acute model of pain, but interaction between these two drugs depends highly on their proportion in the combination. More studies are required to understand the mechanisms and clinical implication of such combinations. The analgesia may increase but adverse effects such as seizurogenic effect of tramadol can be reduced in clinical setting if right proportion is used.
The aim of present study was to investigate the antinociceptive effect of pregabalin and tramadol either alone and or in combination on acute model of pain.
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Learn about drug interactions between amiodarone oral and tramadol oral and use the RxList drug interaction checker to check drug combinations.
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Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed.
tramadol oral brand names and other generic formulations include:
Cordarone Oral, Pacerone Oral.
amiodarone oral will increase the level or effect of tramadol oral by altering drug metabolism.
Interaction is unlikely, minor, or nonsignificant.
amiodarone oral will increase the level or effect of tramadol oral by affecting hepatic enzyme CYP2D6 metabolism.
ConZip Oral, Rybix ODT Oral, Ryzolt Oral, Ultram ER Oral, Ultram Oral.
amiodarone oral brand names and other generic formulations include:
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Never use this combination of drugs because of high risk for dangerous interaction.
Potential for significant interaction (monitoring by your doctor is likely required).
There is a TON of conflicting information regarding the alleged interaction between Tramadol and Methadone; it seems that every idiot wants to come on the And of course, this does not take into account the many cases that were either misdiagnosed, clinically 'insignificant', and overlooked (even with.