RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF DICLOFENAC SODIUM, TRAMADOL HYDROCHLORIDE AND CHLORZOXAZONE FROM THEIR COMBINED TABLET DOSAGE FORM.
Fig. 5: It shows the chromatogram of mixed standard solution containing 60 μg/ml TRM, 400 μg/ml CHL and 80 μg/ml DIC, using mobile phase Acetonitrile: 0.05M Disodium Hydrogen Phosphate buffer pH 3.5 (50:50 v/v) (Proposed Method).
R. Tablet of TRM, DIC and CHL in combined dosage form (TRICARE-MR) was purchased from the local market. Orthophosphoric acid (A.R. Grade) from SD Fines chemicals, Bombay. Grade) was purchased fromSD Fines chemicals, Bombay; Water (HPLC Grade) from RFCL limited, New Delhi; Acetonitrile (HPLC Grade) from RFCL limited, New Delhi and Disodium Hydrogen Phosphate (A.
Table 11: It shows the reproducibility data for DIC (40 μg/ml).
Keywords: Diclofenac sodium, Tramadol Hydrochloride, Chlorzoxazone, RP-HPLC method, Analytical method validation.
Chlorzoxazone/Diclofenac/Tramadol drug information: uses, indications, description, generic name. Compare prices for generic chlorzoxazone/diclofenac/tramadol substitutes: DICLOFON MR.
Max: 150 mg/day. Oral Rheumatoid arthritis; Sprains; Strains; Tendinitis; Pain and inflammation associated with musculoskeletal and joint disorders; Bursitis; Acute gout; Dysmenorrhoea Adult: As diclofenac Na: 75-150 mg/day in divided doses. Hepatic impairment: Dose adjustment may be needed.
Ophthalmic Pain after accidental trauma Adult: As diclofenac Na (0.1% soln): Instill 1 drop 4 times daily for up to 2 days.
Ophthalmic Pain and discomfort after radial keratotomy Adult: As diclofenac Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediay after surgery, and then 1 drop 4 times daily for up to 2 days.
Do NOT chew, break, or split the tablet.
From this yield, 180 μM ONOO– was incubated with 100 μL of each drug; diclofenac sodium 100-500 μg or meloxicam 100-500 μg or tramadol HCl 100-500 in phosphate buffer saline for 15 min and the absorbance at 302 nm of the samples was recorded. All experiments were performed in triplicate. Peroxynitrite mediated.
Then 1 mL of naphthylethylenediamine dihydrochloride was added, mixed and allowed to stand for 30 min in dark place at 25°C. Nitric oxide assay: Nitric oxide radical scavenging was estimated by the use of Greiss reaction (Sundararajan et al., 2006). Greiss reagent was modified by using naphthylethylenediamine dihydrochloride (0.1% w/v). A pink colored chromophore is formed. The reaction mixture was (3 mL) containing sodium nitroprusside (10 mM, 2 mL), phosphate buffer (0.5 mL) and each drug with above concentrations or distilled water as negative control (final volume 0.5 mL) was incubated in dark room at 25°C for 150 min.
Diclofenac and Misoprostol: learn about side effects, dosage, special precautions, and more on MedlinePlus.
Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep this medication in the container it came in, tightly closed, and out of reach of children.
If you become pregnant or think you may be pregnant while taking diclofenac and misoprostol, stop taking the medication and call your doctor immediay. For all patients:. Do not take diclofenac and misoprostol if you are pregnant or plan to become pregnant. Diclofenac and misoprostol may cause miscarriage (pregnancy loss), serious bleeding, or premature birth (baby is born too early) if taken during pregnancy.
Do not take a double dose to make up for a missed one.
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