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The strength that should not be cut in half are the extended release tablets but Tramadol 50 mg is not extended release. Some people are told to start at 25 mg/day to improve tolerability and the lowest strength is 50 mg, so it is safe to cut the tablets . May 15, 2012 . Tramadol hydrochloride is an opioid agonist medication.
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Fixed combination with acetaminophen: Maximum of 75 mg of tramadol hydrochloride (in combination with acetaminophen) every 12 hours.51. Extended -release oral formulations not recommended.53 59 Available tablet or capsule strengths and once-daily dosing do not provide sufficient dosing flexibility for safe use.53.