Ondansetron HCl is a white to off-white powder that is soluble in water and normal saline. Each 1 mL of aqueous solution in the 20-mL multidose vial contains 2 mg of ondansetron as the hydrochloride dihydrate; 8.3 mg of sodium chloride, USP; 0.5 mg of citric acid monohydrate, USP and 0.25 mg of sodium citrate dihydrate.
Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT 3 receptor antagonists.
The adverse reactions in Table 2 have been reported in ≥2% of adults receiving ondansetron at a dosage of 4 mg intravenous over 2 to 5 minutes in clinical trials.
In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), a single maximal daily dose of 8 mg infused over 15 minutes beginning 30 minutes before the start of the emetogenic chemotherapy is recommended.
If intravenous drugs are not mixed but are given consecutively, the infusion line should be flushed through with compatible fluid between each However, a small number of injection solutions are formulated in non-aqueous solvents to allow dissolution of a poorly water soluble substance in a small volume.
Any change in pH towards the other end of the pH scale will reduce the proportion of ionised to un-ionised drug in solution and will therefore reduce the water solubility of the drug. For a drug molecule which acts as a proton acceptor (a Lowry-Bronsted base), ionisation is achieved by formulation in a low pH solution usually as a hydrochloride or hydrogen sulfate salt (for example, amiodarone hydrochloride or adrenaline acid tartrate). The water solubility of any drug is enhanced by ionisation of the molecule.
Cusic, J.W.; U.S. Searle & Co. Searle & Co. Cusic, J.W.; U.S. Patent 2,534,813; December 19,1950; assigned to G.D. Patent 2,499,058; February 28,1950; assigned to G.D.
Used for treating vertigo, motion sickness, and nausea associated with pregnancy.
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Cusic, J.W.; U.S.
Midazolam is a water-soluble benzodiazepine which is used for the same indications as diazepam. It is given by intramuscular injection as a premedication agent and by intravenous injection for sedation and induction. The CSM has received reports of respiratory depression (sometimes associated with.
Remifentanil is given by infusion to supplement anaesthesia. To avoid excessive dosage in obese patients, the dose should be calculated on the basis of ideal body weight. Its rapid metabolism can be advantageous depending upon clinical circumstances. Remifentanil (injection) is an ultra short-acting opioid analgesic. An alternative means of analgesia MUST be established before discontinuing remifentanil infusion.
Fentanyl (injection) has a more rapid onset of action than morphine. It is also useful in reducing the stress of intubation and for short anaesthetic procedures.
Objective: Ketorolac added to tramadol as an injection mixture convenient for clin- Methods: Two different mixtures containing ketorolac tromethamine and tramadol.. tion and solubility. In contrast, weakly acidic ketoro- lac (pKa, 3.54) will exist primarily in an ionized water-soluble form in an alkalinized environment.