Avoid drinking grapefruit juice while you are taking this medication as it can increase the levels of clonazepam in your blood.. tapentadol; tetracycline; theophylline; tocilizumab; topiramate; tramadol; tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine); valerian; zolpidem; zopiclone.
If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. The side effects listed below are not experienced by everyone who takes this medication.
Seizures: For some people taking this medication, seizures may worsen or a new type of seizure can occur. If you experience seizures while taking this medication, contact your doctor immediay.
It can be harmful for people to take this medication if their doctor has not prescribed it. Do not give this medication to anyone else, even if they have the same symptoms as you do.
Stop taking the medication and seek immediate medical attention if any of the following occur:
It is important that the dose be individualized to your specific needs to avoid decreased coordination or excessive drowsiness.
Did you have breathing issues while going to sleep? Yes I went cold turkey and I was on tramadol for about 3 years due to bad back pains at 100-150 mgs 5 days a week. I took grapefruit juice one day and I had a really bad reaction and then about the next week I quit my job so I stopped taking the tramadol.
I appreciate your reply a million! it's great to read from someone who sounds like they know what they're talking about from experience! I hope we can continue the chat. Funny thing is I've been sometimes like a week without tramadol when I went on vacations and I've never had these severer withdrawl reactions. My sleep now is around 4-6 hours, can't complain. I'm so glad to hear you came off these evil damn pills. I didn't see them working enough to continue. I had severe hot and cold reactions, pranoiah, mania, insomnia, trouble breathing you name it.
The idea that drinking a glass of fruit juice could treble the drug levels of certain drugs is a bit disconcerting. To then It is clear that drinking grapefruit juice causes a major increase in drug levels which can lead to serious toxicity. Analgesics: Codeine, Tramadol, Buprenorphine, Oxycodone, Paracetamol.
The net effect of these transporters is hard to predict, as they can have competing actions – sometimes enhancing excretion and sometimes reducing it. Grapefruit juice also has been shown to reduce the plasma concentration of several drugs. Methotrexate levels are thought to be affected by OATP transporters, which are found in the gut, the kidneys, the liver and a few other places. This seems to be caused by the juice inhibiting the organic anion-transporting polypeptide (OATP), which assists in the uptake of drug molecules from the intestinal lumen into the enterocyte.
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