Single-dose oral naproxen for acute postoperative pain: a quantitative systematic review. Lorna Mason,; Jayne E Edwards,; R Andrew Moore author and; Henry J McQuay. BMC Anesthesiology20033:4. https://doi.org/10.1186/1471- . Mason et al; licensee BioMed Central Ltd. 2003. Received: 06 March 2003.
Number of patients with at least 50% pain relief.
The NNTs for naproxen 200 mg (2.3; 1.8 to 3.5) and naproxen sodium 220 mg (13; 3.7 to no benefit) were different in two trials with 122 and 80 patients respectively.
Active treatment and dose (mg) Number of trials Naproxen Placebo.
A low NNT with a narrow confidence interval suggests greater efficacy, and the greater the number of patients in the meta-analysis the more robust the NNT. The number of patients in each meta-analysis from which NNTs have been derived varies considerably, and should be taken into account when comparing NNTs.
Treatment options include a range of drug therapies such as non-steroidal anti-inflammatory drugs (NSAIDs) of which naproxen is one. Naproxen is used to treat a variety of painful conditions including acute postoperative pain, and is often combined with sodium to improve its solubility for oral administration.
A statistically significant benefit of the active treatment over placebo was assumed when the lower limit of the 95% confidence interval (CI) of the relative benefit was more than one. These data were used to calculate the number of patients with at least 50% pain relief for both naproxen and placebo. Relative risk (RR) estimates with 95% confidence intervals were calculated using Meta-view 4.1 in Review Manager (version 4.1) and a fixed effect model ( Morris 1995 ). A statistically significant benefit of placebo over the active treatment was assumed when the upper limit of the 95% CI of the relative benefit was less than one.
Aleve (naproxen) for Pain: "Of the various OTC pain medications I have tried, Aleve has worked the best. Though I'm not so much of a stickler when it comes to only buying name brands (oftentimes I've found that generics work just fine), I find that the name-brand Aleve has more of a positive effect for me than generic.
Did you? Yes No| Report inappropriate. 1 users found this comment helpful.
Hope they have some new ideas. They have all been on my left big toe although currently this one is in my left heel. I made it to November. Have a active lifestyle. Not indocin, naproxen, prednisone nothing! I take Allopurinol daily. I still worry about missing work. I do exercise quite a bit. I’ve worked with my primary physician, podiatrist and now I’m being referred to a Rheumatologist.
Aleve (naproxen): "Hi everyone I'm 42 I just had all my teeth pulled on Oct 6 ,2016. I was in severe pain Felt like my mouth was butchard I took a bottle pain relievers in two days no help so I get a bottle of Aleve 12 hour let me l you it stopped my pain I was so relieved so the meds said take two than 1 every 4 hours so I.
The pain was gone!!!! Fantastic pills.". Could not sleep. Bam. Doc prescribed this piece of brilliance and. "I had terrible ear pain because of wax blockage.
"I have a real problem because no otc medicine works with me so I have to suffer most of the time".
Anonymous (taken for 1 to 6 months) February 25, 2017.
It works very well to stop joint and menstrual pain though and also relaxes my joints and gives greater flexibility.". "Gives me noticeable stomach pain on occasion and I only take when I am desperate due to the risk of it causing stomach ulcers/intestinal bleeding in otherwise healthy people.
I had no inflammation relief either.".
I have had pain since i was 13 from a car accident i was on a bike when hit .recently these people assulted me and stuff and i was perscribed this by the hospital. i was hit in the left jaw with a metal gun barrel and i have t.m.j. in my left jaw getting away i suffered a dental injury on my bottom right jaw area. but on a daily basis.
for high levels of pain and serious permanent injuries or dental pain or t.m.j. no effect. it made me sluggish and tired and that's it. Hide Full Comment. wont help at all. i was hit in the left jaw with a metal gun barrel and i have t.m.j. but on a daily basis i have back rib chest and neck pain from the accident when i was 13 problem. Comment: i have had pain since i was 13 from a car accident i was on a bike when hit. recently these people assulted me and stuff and i was perscribed this by the hospital.