Anesth Analg. 2002 Mar;94(3):619-25; table of contents. Tramadol has no effect on cortical renal blood flow--despite increased serum catecholamine levels--in anesthetized rats: implications for analgesia in renal insufficiency. Nagaoka E(1), Minami K, Shiga Y, Uezono Y, Shiraishi M, Aoyama K, Shigematsu A.
Although NE released from renal sympathetic nerves causes renal hypoperfusion, the effects of tramadol on renal hemodynamics have not been well characterized. Serum NE levels increased up to 176% of control after a 2 mg/kg bolus injection of tramadol. We also studied the effects of tramadol on serum NE levels. Tramadol increased MAP and decreased HR without changing RBF in normal rats at clinical doses. These findings suggest that a bolus injection of tramadol does not alter RBF, although it causes a decrease in HR and an increase in MAP and serum NE in both normal rats and in rats with renal insufficiency. These results suggest that tramadol may have little effect on RBF during the postoperative period. We investigated the effects of tramadol on renal blood flow (RBF), mean arterial blood pressure (MAP), and heart rate (HR) by using a laser Doppler flowmeter, both in normal anesthetized rats and in rats with experimentally-induced nephritis secondary to anti-Thy 1.1 antibody administration. Tramadol is an analgesic that inhibits norepinephrine (NE) reuptake. Tramadol also increased MAP and decreased HR without changing RBF in rats with experimentally induced renal insufficiency. Continuously infused, increasing doses of tramadol (0.5-4 mg.kg(-1).h(-1)) did not affect MAP, HR, or RBF.
A bolus and continuous injection of tramadol does not alter renal blood flow (RBF) in normal rats. These results suggest that tramadol would be a safe analgesic for maintaining RBF during the postoperative period. A bolus injection of tramadol has little effect on RBF in rats with experimentally induced renal insufficiency.
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Abstract: Effect of single and repeated doses of tramadol on hepatic and renal functions and on pentobarbitone anesthesia was evaluated in dogs. Twenty five dogs were randomly distributed into five equal groups viz groups I and II received 3 mg kg-1 of tramadol by subcutaneous and intravenous injections, respectively.