Tramadol hydrochloride tablets are a centrally acting analgesic. The chemical name for tramadol hydrochloride is (±)cis-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride. Its structural formula is: Image from Drug Label Content. Molecular formula: C16H25NO2• HCl Molecular weight: 299.84.
The base is converted to its hydrochloride and recrystallized from a low molecular weight nitrile such as acetonitrile until a greater than 98% trans/cis ratio A hydrochloride of Tramadol can be synthesized without increasing a ratio of trans:cis by including a step in which HCl is added to Tramadol base in.
and filtered and washed with 10 mL acetonitrile. Of this, 40 mL (which has 3.44 g HCl; 94.5 millimoles) was used below. The 40 mL above was added in 10 mL increments and the temperature went up to 35° C. Tramadol base C, 15.4 g and containing 89.8/10.2 trans/cis isomers, was dissolved in 105 mL of dry acetonitrile. Hydrogen chloride gas was bubbled through 40 mL of ice-cooled dry acetonitrile. from 18° C. After 1 hour, the mixture was cooled to 20° C. The weight went up 3.7 g and the volume was measured to be 43 mL.
More from. Tramadol Tablets - FDA prescribing information, side effects and uses; http://www.drugs.com/pro/tramadol-tablets.html; The molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. More from · Side Effects of Ryzolt (Tramadol Hydrochloride.
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The knowledge about the molecular mechanisms, which govern the observed secondary relaxations seems to be the key in predicting the stability of the amorphous form of the examined API. Finally additional dissolving measurements on the amorphous and crystal tramadol hydrochloride were performed.
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TRAMADOL METHOD FOR PREPARATION - The Grignard reaction between 3 bromoanisole and the appropriate Mannich base in the presence of an amine or ether additive gives the amine product in an improved trans/cis ratio. The base is converted to its hydrochloride and recrystallized from a low molecular weight.