Naloxone - as an opioid antagonist - is used to reverse of synthetic and non-synthetic opiate induced respiratory depression. There are some controversies studies about the naloxone and inducing seizure in tramadol poisoning.[15,16,17,18,19,20,21,22,23,24,25,26,27] In animal studies, naloxone reduced the seizure.
Source of Support: Nil.
In the naloxone group, incidence of the need to intubation was significantly higher than the other group ( P <0.05). Clinical outcomes between two groups were followed during the hospitalization period.
National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.
There was no mortality in our cases during the study period, however tramadol-related fatalities has been reported in Iran especially among substance abusers.
While naloxone will reverse some, but not all, symptoms caused by a tramadol (Ultram, ConZip) overdose, the risk of seizures is also increased with naloxone administration with tramadol, and may require treatment with an anti-seizure medication.
We comply with the HONcode standard for trustworthy health information - verify here.
While Narcan can save a life from an overdose, a multi-pronged treatment plan is needed to rescue patients from chronic misuse of opioids. Probuphine consists of four, one-inch-long rods that are implanted under the skin and provide a constant, low-level dose of buprenorphine for six months. As an added weapon in the treatment of opiate addiction, the FDA approved Probuphine in May 2016 as the first buprenorphine implant for the maintenance treatment of opioid dependence.
Alex94. Post 3. @Dinoleash: Narcan (naloxone) is often used to reverse the effects of medications similar to Tramadol. However, studies have shown that, while Narcan can reverse some of the symptoms of the overdose, it can also increase the risk of seizures in a Tramadol overdose.
Note that depending on the number of suggestions we receive, this can take anywhere from a few hours to a few days. Thank you for helping to improve wiseGEEK!. One of our editors will review your suggestion and make changes if warranted.
Alternay, overdose becomes more common when people addicted to tramadol take too much. It can be compley accidental; for instance, a child gets hold of pills that were within his reach. Once a person has received treatment, weigh the risks of an overdose occurring again, particularly if it was the result of addiction, and do what is possible to encourage an addicted person to seek treatment for the condition.
A case study of a tramadol overdose shows a close temporal relationship between naloxone administration and a seizure. While seizure The findings do not suggest that naloxone should be withheld, but that the potential for seizure should be noted and any forthcoming seizure dealt with. More research.
While seizure is a symptom of tramadol intoxication (Saidi et al, 2008), the speed with which it occurred after naloxone administration seemed too fast to be merely coincidence. More research is needed to further define the factors that affect the seizurogenicity of naloxone in tramadol overdose. A case study of a tramadol overdose shows a close temporal relationship between naloxone administration and a seizure. Naloxone is indicated for use by ambulance personnel where the GCS is reduced due to a known, or possible, overdose of an opiate containing substance (JRCALC (Joint Royal Colleges Service Liaison Committee), 2006). A study of the literature shows evidence that naloxone can instigate seizure in the case of a tramadol overdose (Rehni et al, 2008; Raffa and Stone, 2008). The findings do not suggest that naloxone should be withheld, but that the potential for seizure should be noted and any forthcoming seizure dealt with. Tramadol is the most widely prescribed opiate analgesic (National Treatment Agency for Substance Misuse, 2011) and, as a result, is present in a large number of overdoses that present in the pre-hospital arena. This information is particularly pertinent to the ambulance clinician as the consequence of a seizure can be important, both practically and clinically.
4, Iss. 5, 05 May 2012, pp 272 - 276. Journal of Paramedic Practice, Vol.
To view this article You cannot access this article because you do not have a valid subscription. If you have any queries about your account please contact our subscriptions department or ephone free 0800 137201 (UK callers only) or +44 (0)1722 716997 for callers outside the UK. Please use the options below to create a subscription.
Treatment for a Tramadol Overdose. If the overdose was recent, a healthcare provider may induce vomiting or "pump" the stomach. An antidote (naloxone or Narcan) that is often given to reverse the effects of other medications similar to tramadol can help reverse some of the symptoms of an overdose, but this does.
This card is accepted at all major chain pharmacies, nationwide. Our free DiscountRx savings card can help you and your family save money on your prescriptions. Enter your name and address to receive your free savings card.
Raritan, NJ: Ortho-McNeil Pharmaceutical, Inc.;2007 February. Ultram.
Our free DiscountRx savings card can help you and your family save money on your prescriptions. Enter your name and address to receive your free savings card. This card is accepted at all major chain pharmacies, nationwide.