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Okeliten.orgTramadol and blood pressure medication interaction


6.23.2018 | Benjamin MacDonald

Doctor's might consider if blood thinning medication can be reduced if marijuana is indicated.

This study found that THC and especially CBD elevates intracellular levels of Calcium. This effect will may be additive and should be an important consideration when taking medication that affects cellular calcium levels. The study concludes that THC and CBD interact synergistically as well.

Gauging the exact effect of but one drug on an individual is a difficult task, let alone predict the interaction of a half a dozen medications taken simultaneously. Here is what a prominent medical doctor has to say. What's happening to folks and our elderly in particular, is downright scary.

And, of course many over the counter and prescribed drug warnings include drowsiness. What can you say about that kind of statement? Not all Cannabis based meds make you sleepy and for a chronic pain sufferer, a side effect that includes a good night's sleep is a blessing. WebMD chimes in with the opinion that marijuana based drugs are not advised as pain killers because it makes the user sleepy.

Marijuana may increase the amount of drowsiness caused by some drugs.

Again, the positives and negatives of this potential inter-drug reaction should be studied.

Tramadol and blood pressure medication interaction

Click to apply for Medical Marijuana Card renewal.

Marijuana may interfere with the way the body processes certain drugs using the liver's cytochrome P450 enzyme system. As a result, the levels of these drugs may be increased in the blood and may cause increased effects or potentially serious adverse reactions.

"The drugs, including common allergy treatments Piriton and Zantac, as well as Seroxat, an antidepressant, are thought to be used by half of the 10  million over-65s in Britain. Many of the drugs, when taken in combination, were found to more than treble an elderly patient’s chance of dying within two years." - The egraph.

The ratios between CBD (non psychoactive) and THC (psychoactive) dictate largely the pharmacological effects. In addition, Cannabis also contains many terpenes (aromatic compounds), that also have therapeutic effects. Medical grade marijuana should come with a certificate of analysis (cannabinoid profile) that quantifies the main active ingredients THC and CBD as well as several other cannabinoids.

Each variety or strain of marijuana contains a unique assortment of several hundred compounds, many of which are medicinal. The most important and abundant medicinal ingredients in Marijuana are compounds called cannabinoids. To understand medical marijuana's potential interactions with pharmaceutical drugs, one first has to understand what is in the medicine.

Entourage effect of Cannabinoids. Here is a second opinion from a popular medical website.

Pharmacy Times - Drug Interactions with Marijuana.

Marijuana may increase the risk of bleeding when taken with drugs that increase the risk of bleeding.

So no one knows, scientifically, exactly what's going on in your body when you take seven, 10, or a dozen at a time." - Andrew Duxbury, MD, associate professor of geriatrics at the University of Alabama. "The average person over 65 now uses seven different medications per day, four prescribed and three over-the-counter, There's never been a controlled study on a human being involving more than three drugs circulating in the body at the same time.

Cannabinoid-induced alterations in brain disposition of drugs of abuse.

Cannabis based medicines are generally far less toxic than many pharmaceuticals and have fewer side effects, a fact that makes multiple-drug management including MMJ an easier task. In depth knowledge about Cannabis based medicines interaction with prescription drugs is limited due to the herb's unfortunate stint (80 years) as an illegal drug. However, many medical practitioners are equipped with the acumen and experience that will allow them to safely incorporate marijuana into their treatment regimes / repertoires. As such, most orthodox doctors have little experience or training in cannabis based medicines. Until recently, Cannabis has been out of the loop, a non-option, for prescription by medical doctors.

Drugs that May Interact with CBD Oil.

Hypertension is often treated with antihypertensives to lower blood pressure. Some types of marijuana can either lower or raise (speed weed) blood pressure, depending on the strain and the individual. Therefore, patients should monitor the effects of their medications to see that their medication is effective.

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Suppressants and Sleeping aids.

Physicians can consider using Cannabis based medicines to work with other blood pressure lowering medications.

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Pills vs Pot.

Antipsychotic Medications. This caution applies when mixing other stimulants - such as amphetamines, cocaine and coffee - with marijuana. Medications for hypertension or arrhythmias, or patients with cardiovascular issues should be cautious to monitor their response to a new strain of Cannabis.

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complementary and detrimental relationships need to be considered carefully. Medscape on Marijuana.

Differential effects of cannabis extracts and pure plant cannabinoids.

The good news is that the effects of paranoia wear off after a several hours. While this chart might be indicative of the overall situation, there is a significant problem with people freaking out on high THC weed and being admitted to emergency.

Phase II studies of THC:CBD were completed in patients with MS, spinal cord injury, neuropathic pain and a small number of patients with peripheral neuropathy secondary to diabetes mellitus or AIDS. photocredit. GW investigated the use of a sublingual spray containing THC:CBD for pain in spinal cord injury, pain and sleep in MS, spinal cord injury, neuropathic pain in MS and general neuropathic pain. Studies by GW Pharmaceuticals imply that cannabidiol is often better tolerated, is lower in toxicity and has less generally less problematic drug interaction issues. Results from trials showed that THC:CBD caused a statistically significant reduction in neuropathic pain in patients with MS and other conditions. GW Pharmaceuticals is a leader (market cap is $2 billion) in the medical application and research of cannabis based medicines. In addition, improvements in other MS symptoms were observed.

"Well-known brands of hay fever tablets, painkillers and sleeping pills pose a previously unknown threat to people’s health when taken together, British scientists claim." - The egraph.

Marijuana might interfere with drugs used to treat depression and bipolar symptoms. Theophyllines. Currently, there is a lot of interest in how CBD and CBD:THC balanced strains work to help treat psychosis and depression.

There are way too many cases of death caused by lethal drug interactions. Prince, Michael Jackson, Glenn Frey and perhaps soon Hillary Clinton are among the casualties. Which goes to show that even if you have fame and fortune, your exotic cocktail of drugs can easily be fatal. It is known that Percocet and Buprenorphine suppress breathing, and using the two in combination creates a “dangerous synergistic effect.” HOW ABOUT YOU?. In the case of Prince, authorities think a combination of Percocet and Buprenorphine could well have ended the singer’s life prematurely.

Since marijuana comes in so many types, psychoactive, non-psychoactive and many other varieties, the cause and effect should be monitored carefully, particularly when THC is high in the cannabis based medicine.

Drug interactions A Family Guide to Concurrent Disorders - Part III: Treatment.

Marijuana may affect blood sugar levels. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional.

Click to apply first-time medical marijuana patients.

Biological systems are complex and nothing works in isolation. Of course, the pharmaceutical industry want's to isolate and synthesize individual components of marijuana and then study the effects in clinical trials. Calculating the effects of a drug using simple models in this arena of complexity is simply a gross oversimplification of the process. So there is a failure by orthodox medicine to recognize the essential nature of biological systems. The discoverer of THC, Dr. Raphael Mechoulam found out early on that various cannabinoids present in marijuana work in synergy and are more effective / palatable medically when taken together as nature provides.

photo credit 09/23/2016 By 420EvaluationsOnline Staff. We do not diagnose, treat or cure disease. Readers with questions that arise from reading any information on this site should consult a licensed physician or a trusted health professional before taking any medical action. Our medical activities are limited to Medical Marijuana Evaluations and Recommendations within the State of California. Blog, Health & News, Research reports and other documentation at is intended for informational purposes only.

Chart source Drug Wars:

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Marijuana may also interact with agents that; affect blood vessel width, the immune system, be toxic to the liver, improve breathing or treat lung disorders, increase appetite, treat heart disorders, treat nausea or vomiting, treat nervous system disorders, agents that may treat psychiatric disorders, agents that may treat retrovirus infections (HIV), treat skin disorders, treat stomach disorders.

Interactions of cannabis with other drugs in man.


Effects were additive, in the positive and negative directions. In addition, there was a wide variety of responses between individuals and this finding is very significant when predicting impairing effects and pharmaceutical benefits. In this PUBMED report (the world's largest medical document source), it was found that only THC interacted measurable with booze (ethanol) and barbiturates. CBD did not register a notable co- effect with any drug in the study. However, it was speculated that CBD might well moderate or block the action of psychoactive THC, thereby reducing impairment while medicating.

Cannabis is Analgesia, Antiemetic, Appetite Stimulant, Glaucoma.

No standard guidelines exist for dosage ranges. Web MD.

these interactions may mean that marijuana might be used as the lead therapy and other drug doses might be reduced or eliminated entirely.

Cannabis has been shown to increase the metabolism of Theophyllines; which is used to treat asthma and chronic obstructive pulmonary disease. Cannabis might be useful to lower the dose of theophyllines required. FURTHER READING.

Cannabis can make anti-antihistamines more potentiated and drowsiness may result, so lowering the dose might be required. Cannabis can can amplify some of the effects of alcohol, which is true of many other medicines.

Doctor's can observe cause and effect, and regulate insulin and cannabis medication accordingly.

Marijuana can definiy interact - positively or negatively - with your medication. The quick and dirty answer is YES.

You never know when a particular combination will produce a lethal outcome.” - Joe Graedon. This is a crazy world where one plus one equals three, where down may very well be up and surely pigs have wings. In fact, mixing medicines is very much like playing Russian roulette. “Drug interactions are the Achilles heel of the medical profession. The laws of nature no longer hold true.

Tricyclic antidepressants and SNRIs.

Pretreatment with CBD enhanced the brain levels of subsequent uptake of both THC and Cocaine while co-effects were negligible with morphine, methadone, o methamphetamine. These results imply that CBD may be useful to enhance the uptake of certain drugs while lowering the dose and side effects.

This group warns that marijuana is addictive, which flies in the face of most current research and statistical evidence. Caffeine, alcohol, nicotine and marijuana interaction with pharmaceutical drugs is discussed. While marijuana might cause an addiction for some, like Jim Carrey, who feels like he's on holiday too much, most studies find that cannabis has the lowest addiction rate of any of the major drugs, legal and illegal.

How to Safely Combine Medical Marijuana with Pharmaceuticals.

Labels: drugs prescription medication pharmaceutical cannabis marijuana interact side-effect prescribe doctor MD toxic titrate.

Dosing of marijuana preparations is highly dependent on a variety of factors (eg, growing and harvesting conditions, plant parts isolated).

"Entourage effect is a phrase that was introduced in cannabinoid science in 1998 by S. Ben-Shabat, with Raphael Mechoulam, to represent a novel endogenous cannabinoid molecular regulation route. Biological activity assayed together with inactive compounds. References whole-plant and whole-person caregiver synergy treatments over isolated compound pharmacological dosage."- Wiki.

When cannabinoids are mixed with other suppressants, sleeping aids and such, the effect can often be additive. If a patient is using drugs like Sonata, Lunesta, Ambien; and Zimovane and the practicing physician is interested in prescribing cannabinoids, then the dose of the pharmaceuticals may well need to be reduced or eliminated entirely. Anti-antihistamines.

Tachycardia and hypertension may occur when marijuana is combined with stimulants.

Mayo's findings are summarized in bullet point, click on the Mayo Clinic link (title) for details.


Cannabis was often prescribed with opium before 1930 for pain. The strategy of some physicians is to try dosing with moderate amounts of Cannabis medicines with different ratios of CBD and THC and then consider adding other drugs as required. The effect of prescription drugs can be compounded – or weakened – when combined with Cannabis. this is great news, but the additive good effects could be too much of a good thing. Over relaxation and drowsiness of these two drugs in combination could be fatal. Recently, some physicians report that patients using cannabis with non-steroidal anti-inflammatories have better relief of pain. It should be noted that Cannabis use alone has seldom, if ever caused death alone.

Can Marijuana cause dangerous interactions with my medication too? What kind of interactions should my doctor look for? Can Medical Marijuana replace or lower the dose of some of my existing medication?

A Deadly Drug Interaction Often Ignored by Doctors and Pharmacists.

Caution is advised in people taking drugs that lower blood pressure. Marijuana may cause low blood pressure.

Blood sugar lowering meds.

GW Pharmaceuticals Research on Cannabinoid Medical Applications.

Paul Hornby, a PhD. Fold musician, Neil Young recently shared his findings that chewing on a few black peppercorns (full of terpenes) stops feelings of paranoia that can happen even with experienced users. Dr. in pathology and medical marijuana guru of sorts has found that THC and CBD interact to produce a balancing effect mentally, whereas THC alone can cause temporary psychosis.

Drugs include amitriptyline, amoxapine and desipramine. Both cannabis based medicines and tricyclic antidepressants or other drugs (SNRIs) that inhibit the uptake of serotonin and norepinephrine are used in anxiety disorders, obsessive-compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and PMS. When combined with Cannabis there is a potential of interaction, an increase in drowsiness and sedation. Stimulants.

Cannabis based medicines can interact with anabolic steroids, anticancer agents, antipyrine, antiseizure agents, bromo-dragonFLY, cannabinoid CB1 receptor antagonists, central nervous system depressants, cocaine, corticosteroids, dopamine antagonists, ecstasy, estrogens, fertility agents, hormonal agents, nicotine, nonsteroidal anti-inflammatory agents, opioid receptor antagonists, pain relievers, p-glycoprotein-regulated agents, prochlorperazine, sedatives, and synthetic cannabinoids.

Some types of cannabis were shown to interfere with the effectiveness of Metformin. Antihypertensives. Diabetics take warning, blood sugar lowering Metformin and Glucophage, interacts with Cannabis.

This group knows about marijuana based medicines and provides clinical evidence about potential drug interactions.

Access to lab tested marijuana, complete with an accurate cannabinoid profile is very important to identify the medicine that is best for a given condition or symptom. Patients that are concerned about Marijuana and potential drug interactions should consult a medical doctor or healthcare professional with deep experience cannabis based medicine. To purchase lab tested marijuana in the State of California, patients need a recommendation from a licensed physician.

Of course, the question about drug administration and interactions is best answered by medical practitioners with deep experience in recommending medical marijuana.

Tramadol and blood pressure medication interaction