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2007 Oct; 3(5): 819–829. Many have been living with their pain for more than 5 years and experience pain almost 6 days a week.. formulations of tramadol, have been recently marketed in various countries, with the aim of providing continuous drug delivery and corresponding analgesic efficacy over 24 hours.

In osteoarthritis patients (double-blind study), pain relief was superior with oral tramadol 300 mg than with oral dextropropoxyphene 300 mg ( Jensen et al 1994 ). Similarly, in a double-blind crossover trial, tramadol 200 mg was shown to be more effective than pentazocine 150 mg ( Bird et al 1995. In the treatment of severe pain from osteoarthritis, similar pain relief was achieved with both long-acting tramadol and dihydrocodeine with NSAID’s, but tramadol interfered less with intestinal function ( Wilder-Smith et al 2001 ).

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