The aim of present preview is to consider the manifold and multiplex nature of pharmacological drug-drug interaction in the general dental practice. In the case of codeine, the active demethylated metabolite morphine & the parent molecule, in case of tramadol, appears to possess analgesic activity by.
Due to short-term duration of therapy and the relative low doses that are prescribed, serious adverse drug interactions involving them are rarely reported. Analgesic Agents: The use of analgesics is widespread, in dental or periodontal practice.
Well recognized biochemical target is the cytochrome P450 system for vast majority of drug metabolic interactions, a group of heme-containing enzymes embedded in the smooth endoplasmic reticulum of hepatocytes and enterocytes of liver and small intestine respectively.
Drugs with a narrow therapeutic range or low therapeutic index are more likely to be the objects for serious drug interactions. Warfarin (Coumadin) plus ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin, metronidazole (Flagyl) or trimethoprim-sulfamethoxazole SSRI plus tramadol (Ultram).
Monitor phenytoin levels. Clinical significance has not been established. Phenobarbital plus rifampin Decreased phenobarbital levels.
Increased bleeding, increased INR Any time.
SSRI plus tramadol (Ultram).
Sildenafil plus cimetidine, erythromycin, itraconazole or ketoconazole Increased sildenafil levels Any time.
Decreased effectiveness of oral contraception Any time.
SSRI plus tricyclic antidepressant.
Possibly after initial dose.
Oral contraceptive pills plus rifampin.
Generally within 1 week Monitor phenytoin levels.
Increased effect of warfarin.
Phenobarbital plus cimetidine, erythromycin, clarithromycin or fluconazole Increased phenobarbital levels.
Find patient medical information for Metronidazole Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Before using this medication, l your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, certain blood disorders (low blood cell counts).
This medication passes into breast milk. If you are prescribed the single-dose treatment, your doctor may direct you to stop breast-feeding for a short time after the dose. Discuss the risks and benefits with your doctor before breast -feeding. Consult your doctor for more details.
Does Metronidazole interact with other medications?
Before taking metronidazole, l your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as tinidazole ); or if you have any other allergies.
Learn about side effects, interactions and indications. Do not drink alcohol or consume foods or medicines that contain propylene glycol while you are taking metronidazole and for at least 3 days after you stop Do not take this medicine in larger or smaller amounts or for longer than recommended.
Using metronidazole during pregnancy could harm the unborn baby. l your doctor if you are pregnant or if you become pregnant while using this medicine.
vaginal itching or discharge; mouth sores; or.
Store at room temperature away from moisture and heat. Dosage Information (comprehensive).
muscle weakness, problems with coordination;
Last reviewed: November 07, 2017 Date modified: October 24, 2017 Availability Prescription only.
Metronidazole is usually given for up to 10 days in a row. You may need to repeat this dosage several weeks later.
We comply with the HONcode standard for trustworthy health information - verify here.
Metronidazole will not treat a vaginal yeast infection.
Get emergency medical help if you have signs of an allergic reaction to metronidazole : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
a blood cell disorder such as anemia (lack of red blood cells) or low white blood cell (WBC) counts;
Do not crush, chew, or break an extended-release tablet.
In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute.
STD Prophylaxis azithromycin, doxycycline, metronidazole, Zithromax, ceftriaxone, Flagyl, More.
Pregnancy Category No proven risk in humans.
Type in a drug name and select a drug from the list.
Trichomoniasis metronidazole, Flagyl, tinidazole, Tindamax, More.
Do not stop taking any medications without consulting your healthcare provider.
Show all medications in the database that may interact with Flagyl IV (metronidazole).
Dental Abscess amoxicillin, metronidazole, Flagyl, erythromycin, clarithromycin, Amoxil, More.
A total of 357 drugs (1410 brand and generic names) are known to interact with Flagyl IV (metronidazole).
Subscribe to receive notifications whenever new articles are published.
→ Here are 9 ways to stay safe Availability Prescription only.
provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.